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I'm no veteran, and this is my first time doing something like this, but I'll still offer my two cents. Hopefully this'll be of some use to you.
You can cancel the animation lock on Active: Mana Phase and still gain the buff.
You can shorten animation locks after combos by holding in Right-Click until Mana Munitions appears then letting go.
Alternatively, you can chain into another combo by using Warp Shot (TAB) after your combo.
As well as using Warp Shot (TAB) to chain together attacks, it is also useful for manoeuvring around enemies to avoids attacks. Just be careful, you're vulnerable while entering the warp, but after that you're safe.
Mana Munitions (Right-Click+WAD) adds a damage buff and other goodies, don't forget to use them.